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Exercise‐induced increments in plasma levels of propranolol and noradrenaline.
Author(s) -
Hurwitz GA,
Webb JG,
Walle T,
Bai SA,
Daniell HB,
Gourley L,
Loadholt Boyd C,
Gaffney TE
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02228.x
Subject(s) - propranolol , medicine , endocrinology , placebo , physical exercise , treadmill , bicycle ergometer , chemistry , heart rate , blood pressure , alternative medicine , pathology
Exercise‐induced changes in the plasma levels of propranolol and noradrenaline were determined in nine volunteers. Total plasma propranolol levels were increased during submaximal treadmill exercise, with exercise‐induced increments of 13 +/‐ 4% at 4 h after the last dose, 18 +/‐ 7% at 9 h and 41 +/‐ 5% at 16 h. Exercise‐induced increments in plasma propranolol were observed after single as well as repeated doses. During exercise, increments in plasma propranolol were correlated temporally with changes in plasma noradrenaline. Exercise‐ induced increments in plasma noradrenaline were greater during propranolol administration than during placebo periods. The changes in plasma propranolol concentration during exercise may reflect a redistribution of propranolol at its site(s) of action.