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Effects of beta 1‐adrenoceptor agonism on plasma renin activity in normal men.
Author(s) -
Staessen J,
Cattaert A,
Schaepdryver A,
Fagard R,
Lijnen P,
Moerman E,
Amery A
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02215.x
Subject(s) - plasma renin activity , medicine , heart rate , endocrinology , blood pressure , renin–angiotensin system , beta (programming language) , supine position , agonism , saline , agonist , chemistry , receptor , politics , computer science , political science , law , programming language
The contribution of beta 1‐adrenoceptors to the regulation of plasma renin activity was investigated in nine healthy sodium‐replete volunteers: seven subjects received a cumulative intravenous dose of 75 micrograms/kg prenalterol, a predominant beta 1‐adrenoceptor agonist, and two subjects only vehiculum. In the seven actively treated subjects beta 1‐adrenoceptor agonism increased (P less than 0.001) systolic intra‐arterial pressure by an average of 16 +/‐ 4 mm Hg and heart rate by 19 +/‐ 3 beats min. These increases were significantly (P less than 0.04) different from the changes observed in the two control subjects (+ 3 +/‐ 4 mm Hg and ‐1 +/‐ 4 beats/min, respectively). Plasma renin activity, however, tended to decrease in both the actively (‐38%) and saline (‐28%) treated subjects. Predominant beta 1‐adrenoceptor agonism, powerful enough to increase systolic pressure and heart rate does not increase plasma renin activity in supine sodium‐replete normal man.