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Serum protein binding of propylthiouracil.
Author(s) -
Kampmann JP,
Hansen JE Molholm
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02214.x
Subject(s) - propylthiouracil , antithyroid agent , plasma protein binding , medicine , pharmacology , chemistry , endocrinology , graves' disease , thyroid
Serum protein binding of propylthiouracil (PTU) was measured by ultrafiltration in healthy and hyperthyroid patients. The serum protein binding in 12 euthyroid subjects was 76.2 +/‐ 1.2% (mean +/‐ s.d.), not significantly different from the values in 10 hyperthyroid patients: 76.6 +/‐ 1.3% Binding was unaffected by incubation time and temperatures between 25 and 37 degrees C, but increased from 76.5 to 79.1% when pH changed from 7.4 to 7.9. PTU is predominantly bound to albumin with two classes of binding groups with different number of binding sites and affinity. Displacement experiments showed interaction with acetylsalicylic acid, warfarin and phenylbutazone, but not with antipyrine and nortriptyline or other basic drugs.