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Mitochondrial respiration inhibitors and human sperm motility: implication in the development of spermicides.
Author(s) -
Hong CY,
Chiang BN,
Wei YH
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02204.x
Subject(s) - motility , respiration , mitochondrion , cellular respiration , sperm motility , sperm , chemistry , pharmacology , biochemistry , biology , medicine , andrology , microbiology and biotechnology , anatomy
Three inhibitors of the mitochondrial respiratory chain, rotenone, antimycin A, potassium cyanide and the uncoupler of oxidative phosphorylation, 2,4‐dinitrophenol, were tested for their sperm immobilizing effects with a trans‐membrane migration method. None of these drugs inhibited human sperm motility at the concentrations of 10(‐ 6), 10(‐5), 10(‐4) and 10(‐3) M. The suggestion to develop spermicidal contraceptives from mitochondrial respiration inhibitors could not be substantiated; and the theory that motility inhibiting drugs act primarily on the sperm membrane was reconfirmed.