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The effect of cimetidine on tolbutamide kinetics.
Author(s) -
Dey NG,
Castleden CM,
Ward J,
Cornhill J,
McBurney A
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02192.x
Subject(s) - tolbutamide , cimetidine , pharmacology , medicine , plasma concentration , chemistry , endocrinology , diabetes mellitus
Although possible on theoretical grounds, no interaction between cimetidine and tolbutamide could be demonstrated in ten healthy volunteers. The plasma tolbutamide concentrations over 12 h following 0.5 g orally were essentially the same before and after 1 and 7 days cimetidine (400 mg twice daily).