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The effect of a 5‐HT antagonist, ketanserin, on blood pressure, the renin‐angiotensin system and sympathoadrenal function in normal man.
Author(s) -
Zoccali C,
Zabludowski JR,
Isles CG,
Murray GD,
Inglis GC,
Robertson JI,
Fraser R,
Ball SG
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02166.x
Subject(s) - ketanserin , endocrinology , medicine , blood pressure , renin–angiotensin system , plasma renin activity , aldosterone , antagonist , angiotensin ii , serotonin , 5 ht receptor , receptor
The role of endogenous 5‐hydroxytryptamine (5‐HT) in the control of blood pressure, the renin‐angiotensin system and sympatho‐adrenal function was investigated in normal man. Ketanserin (a specific 5‐HT2 antagonist) administered intravenously caused a small decrease in blood pressure in salt‐depleted recumbent subjects. A more marked postural fall in pressure occurred in both sodium‐depleted and repleted normal subjects. Plasma active renin concentration and angiotensin II increased after administration of ketanserin, but plasma aldosterone, cortisol and noradrenaline were unchanged. 5‐HT may be important in the control of blood pressure in man and specific 5‐HT2 receptor antagonists could be a useful new class of antihypertensive agents.