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Acebutolol pharmacokinetics in renal failure.
Author(s) -
Smith RS,
Warren DJ,
Renwick AG,
George CF
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02158.x
Subject(s) - acebutolol , renal function , metabolite , pharmacokinetics , creatinine , renal physiology , medicine , half life , endocrinology , chemistry , pharmacology , urology , blood pressure
Acebutolol was administered orally in a single dose of 200 mg to 17 individuals whose renal function varied markedly. The plasma half‐life and elimination rate constant for acebutolol showed a four‐fold variation but these did not correlate with the degree of renal impairment. However, there was a good correlation between the renal clearance of creatinine and that of acebutolol (P less than 0.001). The half‐life and elimination rate of the acetyl metabolite, diacetolol, were subject to 10‐fold inter‐individual variability which correlated significantly with the creatinine clearance and serum creatinine concentration. The AUC for the acetyl metabolite showed a 40‐fold individual variation which also correlated with renal function. It is concluded that renal elimination is the principal route of excretion for diacetolol but not the parent compound, acebutolol.