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Absorption of orally administered amphotericin B lozenges.
Author(s) -
Ching MS,
Raymond K,
Bury RW,
Mashford ML,
Morgan DJ
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02152.x
Subject(s) - lozenge , amphotericin b , medicine , pharmacology , oral administration , pharmacokinetics , absorption (acoustics) , orally active , anesthesia , dermatology , antifungal , physics , archaeology , acoustics , history
The systemic absorption of amphotericin B, administered as a 10 mg lozenge, was investigated in 14 patients with malignancies, who received three or four doses daily during chronic administration. The mean plasma amphotericin B concentration, measured 3 h after the morning dose on from 1‐20 occasions over a 1‐80 day period, ranged among subjects from 46 +/‐ 13 ng/ml (s.d., n = 20) to 136 +/‐ 25 ng/ml (n = 19). Using the previously reported intravenous clearance of the drug, the fraction of the dose absorbed was estimated at 8.3‐9.9%. This is considerably greater than that estimated from earlier reports (0.2‐ 0.9%), which used much higher oral doses (2‐10 g/day).