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Effect of urine pH on the elimination of phenoperidine.
Author(s) -
Milne LA,
Williams NE,
Calvey TN,
Murray GR,
Chan K
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02150.x
Subject(s) - urine , chemistry , pharmacokinetics , metabolite , chromatography , pharmacology , biochemistry , medicine
The effect of urine pH on the plasma concentration and elimination of phenoperidine and its main metabolites was studied in six volunteers. The clearance of unchanged phenoperidine in acid urine was significantly greater than in neutral or alkaline urine. By contrast, the elimination of its basic metabolites was enhanced in uncontrolled or alkaline urine. Other pharmacokinetic parameters were not significantly affected.