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Pharmacokinetics of ketoprofen in the elderly.
Author(s) -
Advenier C,
Roux A,
Gobert C,
Massias P,
Varoquaux O,
Flouvat B
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02145.x
Subject(s) - ketoprofen , pharmacokinetics , medicine , oral administration , significant difference , pharmacology
Pharmacokinetic constants of ketoprofen (Orodis, Profenid) were determined in 10 young adults (24.9 +/‐ 1.3 years) and seven elderly patients (86.3 +/‐ 2.4). Following oral administration of a 150 mg dose of ketoprofen, no difference in tmax was observed between the two groups. However, compared with younger subjects elderly patients showed a significant increase in t1/2,z (2.72 +/‐ 0.22 vs 1.77 +/‐ 0.16 h; P less than 0.01) and AUC (70.4 +/‐ 6.4 vs 29.13 +/‐ 2.02 mg l‐1 h; P less than 0.001), a non‐significant reduction of Vd/F per kg bodyweight (0.145 +/‐ 0.016 vs 0.213 +/‐ 0.028 l kg‐1) and a decrease in total clearance CLT/F (0.037 +/‐ 0.002 vs 0.071 +/‐ 0.004 l h‐1 kg‐1, P less than 0.05). These results suggest that the glucuroconjugation of ketoprofen is slowed down by age.