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A double‐blind placebo‐controlled study of fluvoxamine and imipramine in out‐patients with primary depression.
Author(s) -
Itil TM,
Shrivastava RK,
Mukherjee S,
Coleman BS,
Michael ST
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02134.x
Subject(s) - fluvoxamine , imipramine , placebo , clinical global impression , hamilton rating scale for depression , beck depression inventory , medicine , anesthesia , psychology , psychiatry , mood , fluoxetine , major depressive disorder , anxiety , serotonin , receptor , alternative medicine , pathology
1 A double‐blind placebo‐controlled study of fluvoxamine and imipramine was performed in a group of depressed patients. Twenty‐two patients received fluvoxamine (mean dose 101 mg/day), 25 received imipramine (mean dose 127 mg/day) and 22 received placebo. 2 Apart from an increase in the SGOT and SGPT values of four imipramine patients, no statistically significant changes in haematology or urinalysis were judged to be medically relevant. Fluvoxamine exhibited fewer anticholinergic side effects than imipramine. 3 Both fluvoxamine treated patients and imipramine‐treated patients exhibited a statistically significant improvement at the end of the 28‐day treatment period with respect to the placebo patients, as measured using the Hamilton Rating Scale for Depression, and the Clinical Global Impression Scale. Evaluations of the results of the Beck Depression Inventory and the Profile of Mood States revealed a statistically significant improvement for imipramine patients with respect to placebo at week 4, but not for fluvoxamine patients. It is postulated on the basis of quantitative pharmaco‐EEG findings, that the slight superiority of imipramine over fluvoxamine was due to underdosing of the latter.