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5‐hydroxytryptamine and depression: a model for the interaction of normal variance with pathology.
Author(s) -
Goodwin FK,
Post RM
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02130.x
Subject(s) - depression (economics) , aggression , imipramine , impulsivity , metabolite , platelet , serotonin , poison control , medicine , endocrinology , psychology , clinical psychology , psychiatry , pathology , medical emergency , receptor , alternative medicine , economics , macroeconomics
1 Theories linking 5‐hydroxytryptamine (5‐HT) with depression are briefly reviewed. The various experimental strategies adopted to investigate this relationship, examination of autopsy data, CSF metabolite data, 5‐HT re‐uptake patterns in human blood platelets and imipramine binding studies in human platelets, are discussed. 2 Recent studies of 5‐hydroxyindole acetic acid (5‐HIAA) levels in cerebrospinal fluid have revealed a linkage between low 5‐HIAA levels and suicide, aggression and impulsivity. Decreases in the number of imipramine binding sites have also been found in brains of suicide victims. 3 The available data lead to the conclusion that decreased 5‐ hydroxytryptaminergic function may be associated with an increased risk of depression, suicide, and some types of aggression.