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Haemodynamic and metabolic effects of dazoxiben at rest and during atrial pacing.
Author(s) -
Kiff PS,
Bergman G,
Atkinson L,
Jewitt DE,
Westwick J,
Kakkar VV
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02112.x
Subject(s) - medicine , cardiology , angina , hemodynamics , thromboxane b2 , thromboxane , coronary sinus , pulmonary artery , anesthesia , platelet , myocardial infarction
1 Thromboxane B2 (TXB2) levels were measured in three sites (coronary sinus, pulmonary artery, and femoral artery) at rest and during atrial pacing in 11 patients with stable angina pectoris. 2 There was a highly significant increase in arterial TXB2 on pacing (by up to 820 pg/ml) but there was no change in the thromboxane levels at the other two sites. 3 Dazoxiben 200 mg orally abolished the increase in arterial TXB2, but had no effect on systemic, pulmonary or coronary haemodynamics, no effect on myocardial metabolism and a variable effect on atrial pacing time to angina.