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Effect of dazoxiben on platelet‐vessel wall interaction.
Author(s) -
Davies JA,
Menys VC
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02106.x
Subject(s) - prostacyclin , platelet , aorta , thromboxane a synthase , adhesion , thromboxane b2 , thromboxane , perfusion , chemistry , prostaglandin , medicine , biochemistry , organic chemistry
1 Platelet monolayer adhesion to damaged rabbit aorta and to collagen‐ coated glass was quantified in a perfusion device. Addition of the thromboxane synthetase inhibitor dazoxiben (UK 37248) 1 and 10 microM reduced adhesion to damaged blood vessel by about 45% at both concentrations, but did not affect adhesion to collagen‐coated glass. 2 Measurement by RIA indicated virtual abolition of thromboxane B2 production in the presence of the drug and a slight trend to an increase of 6‐oxo‐prostaglandin F1 alpha concentration in experiments using aorta. Inhibitory activity of dazoxiben was abolished by previous exposure of the aorta to 15‐HPETE(?), an inhibitor of prostacyclin synthetase. 3 The results indicate that dazoxiben inhibits platelet adhesion to vascular subendothelium possibly by promoting synthesis of PGI2 from re‐directed platelet endoperoxides.