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Conversion in vitro of urinary (+)‐penicillamine to its major metabolites, PSSP and PSSC.
Author(s) -
Carruthers G,
Weir D,
Freeman D,
Harth M
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb01563.x
Subject(s) - penicillamine , urinary system , metabolite , in vitro , pharmacology , urine , chemistry , medicine , biochemistry
To investigate the discrepancy between the apparent pharmacokinetic disposition of (+)‐penicillamine in plasma and urine, the spontaneous degradation of (+)‐penicillamine was studied in acidified and non‐ acidified urine. Degradation was prevented by acidification. The oxidized metabolites were converted to reduced (+)‐penicillamine by electrolysis.