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The influence of food intake on the bioavailability of timegadine, a novel non‐steroidal anti‐inflammatory drug.
Author(s) -
George S,
Dauwe K,
McBurney A,
Ward J
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb01537.x
Subject(s) - bioavailability , cmax , ingestion , drug , absorption (acoustics) , pharmacology , pharmacokinetics , plasma concentration , chemistry , area under the curve , food science , medicine , physics , acoustics
The effects of food ingestion on the absorption of timegadine, a recently synthesised non‐steroidal anti‐inflammatory drug, was studied in ten healthy volunteers. It was found that food enhanced the absorption of timegadine as shown by increased peak plasma concentrations (Cmax), decreased time taken to achieve these concentrations (tmax), and increased area under the plasma concentration time curve (AUC).