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Absorption of beta‐adrenoceptor antagonists to Amberlite resin.
Author(s) -
Heath A,
Gabrielsson M,
Redgardh CG
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb01535.x
Subject(s) - atenolol , alprenolol , practolol , propranolol , chemistry , amberlite , pharmacology , partial agonist , adsorption , oxprenolol , metoprolol , chromatography , extraction (chemistry) , beta (programming language) , agonist , medicine , anesthesia , receptor , biochemistry , organic chemistry , blood pressure , computer science , programming language
The adsorption of beta‐adrenoceptor blockers and the partial beta‐ adrenoceptor agonist prenalterol was studied in an in vitro haemoperfusion (HP) model. Metoprolol, alprenolol, propranolol and prenalterol adsorb well from the blood to the resin with extraction ratios nearing 1.0. Extraction ratio for practolol was 0.68 and for atenolol 0.49. Protein binding has little effect on the degree of adsorption, which is more dependent on water solubility.