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Reproducibility of saliva and plasma theophylline levels following single dose administration of two sustained release preparations.
Author(s) -
Jackson AH,
Edwards C,
Cope AS,
Stockley RA,
Purkiss R
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb01522.x
Subject(s) - saliva , theophylline , reproducibility , plasma concentration , medicine , plasma levels , concomitant , oral administration , chemistry , pharmacokinetics , pharmacology , endocrinology , chromatography
1 Concomitant saliva and plasma theophylline concentrations were measured in six healthy male volunteers following single dose administration of two sustained release preparations (Nuelin SA and Phyllocontin Continus). 2 Using mean values, a good correlation was obtained between saliva and plasma drug concentrations. Prediction of plasma values using individual saliva was poor and varied widely. The ratio of saliva to plasma concentrations in the same individual, assessed under standardised conditions, was not always reproducible.