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Kinetics of oral trifluoperazine disposition in man.
Author(s) -
Midha KK,
Korchinski ED,
Verbeeck RK,
Roscoe RM,
Hawes EM,
Cooper JK,
McKay G
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb01515.x
Subject(s) - trifluoperazine , ingestion , oral administration , disposition , pharmacokinetics , chemistry , pharmacology , plasma concentration , medicine , biochemistry , enzyme , psychology , social psychology , calmodulin
The disposition of trifluoperazine (TFP) was studied in five healthy volunteers following oral administration of a 5 mg tablet. Using a very sensitive GC‐MS technique plasma TFP concentrations were measured up until 24 h following drug ingestion. Peak plasma concentrations varied widely (range 0.53‐3.09 ng ml‐1) and were reached 2.8 +/‐ 0.5 h following ingestion of the TFP tablet. The apparent terminal elimination half‐life of TFP was 12.5 +/‐ 1.4 h. The area under the plasma concentration‐time curve differed widely between subjects (range: 5.9‐17.6 ng ml‐1 h) suggesting large individual differences in the extent of presystemic TFP elimination.