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Lack of effect of ranitidine on the disposition of lignocaine.
Author(s) -
Feely J,
Guy E
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb01514.x
Subject(s) - cimetidine , ranitidine , histamine , disposition , histamine h2 receptor , pharmacology , placebo , antagonism , medicine , drug interaction , distribution (mathematics) , anesthesia , pharmacokinetics , antagonist , receptor , psychology , social psychology , mathematical analysis , alternative medicine , mathematics , pathology
Cimetidine has been shown to alter the disposition of lignocaine and other drugs that are highly extracted by the liver. In a placebo controlled study ranitidine (150 mg twice daily) did not alter the elimination half‐life, systemic clearance or distribution of lignocaine (mg/kg) in six healthy subjects. The interaction with cimetidine appears to be unrelated to histamine H2‐receptor antagonism.