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A method to prevent the loss of isoniazid and acetylisoniazid in human plasma.
Author(s) -
Hutchings A,
Monie RD,
Spragg B,
Routledge PA
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb01496.x
Subject(s) - isoniazid , plasma concentration , plasma , chemistry , human plasma , half life , pharmacokinetics , chromatography , pharmacology , medicine , tuberculosis , physics , pathology , quantum mechanics
Plasma concentrations of isoniazid and N‐acetylisoniazid were measured at varying times after addition of both compounds to plasma (5 micrograms/ml) and storage at several different temperatures (−70 degrees C, −20 degrees C, 4 degrees C and 20 degrees C). The concentration of both compounds declined log‐linearly with time and the half‐life of decline was shorter with increasing temperature of storage. Both compounds were stable for at least 5 weeks, however, when stored at −070 degrees C. We conclude that this temperature should be used to prevent loss of both compounds during storage and transport of samples.