Premium
Standardised isoprenaline sensitivity tests‐a comparison of existent methods.
Author(s) -
Arnold JM,
McDevitt DG
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb01482.x
Subject(s) - isoprenaline , heart rate , medicine , anesthesia , cardiology , blood pressure , stimulation
1 Six healthy subjects (four male, two female, aged 19‐24 years) received intravenous boluses of isoprenaline sulphate by two standardised methods of injection (Cleaveland et al., 1972; George et al., 1972). Heart rate changes were analysed by three different methods. 2 The I25 (dose of isoprenaline required to increase the heart rate by 25 beats/min) was not significantly altered by either the method of injection or the method of heart rate measurement. 3 The slope of the heart rate dose response curve was significantly steeper when isoprenaline was injected in a fixed 2 ml volume through a three‐ way tap, and when the heart rate was measured from the shortest three R‐ R intervals. 4 However the differences in method of injection and heart rate measurement between the two techniques do not appear to produce major alterations in the results obtained, particularly the I25.