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Acute haemodynamic effects of a new calcium antagonist, nicardipine, in man. A comparison with nifedipine.
Author(s) -
Iliopoulou A,
Turner P,
Warrington SJ
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb01464.x
Subject(s) - nicardipine , nifedipine , medicine , placebo , blood pressure , heart rate , hemodynamics , anesthesia , antagonist , systole , ejection fraction , diastole , cardiology , calcium , heart failure , alternative medicine , receptor , pathology
1 The acute cardiovascular response to nicardipine was investigated using non invasive techniques in normal subjects. 2 In six subjects, i.v. nicardipine in an increasing dose (0.5‐20 mg) was compared with saline, under double‐blind conditions. A dose related increase in heart rate and fall in blood pressure were found. Pre‐ejection period (PEP) and PEP/left ventricular ejection time (LVET) ratio of the systolic time intervals were shortened in a clearly dose related manner. Total electromechanical systole index (QS2 I) was decreased and LVET index prolonged. 3 In four subjects increasing oral doses (10‐40 mg) of nicardipine, administered in a randomized double‐blind placebo control design, demonstrated the same pattern, marked changes being found with the 40 mg dose. 4 Comparison with nifedipine in a double‐blind‐placebo controlled balanced trial in six subjects confirmed that 40 mg nicardipine and 20 mg nifedipine exhibited similar effects. Maximum response was reached between 0.5 and 1.5 h, and changes in some cardiovascular variables were still evident at 3 h.