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CENTRAL α 2 ‐ADRENOCEPTORS AND BLOOD PRESSURE REGULATION IN MAN: STUDIES WITH GUANFACINE (BS100‐141) AND AZEPEXOLE (BHT 933)
Author(s) -
REID J.L.,
RUBIN P.C.,
HOWDEN C. W.
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb00312.x
Subject(s) - guanfacine , blood pressure , supine position , medicine , sedative , dosing , hemodynamics , anesthesia , pharmacology , clonidine
1 The haemodynamic and sedative actions of guanfacine and azepexole, two α 2 adrenoceptor agonists, have been examined in hypertensive patients and normotensive subjects, respectively. 2 After oral dosing both drugs lowered supine and erect blood pressure, reduced plasma noradrenaline and caused subjective drowsiness lasting for 6–8 h. 3 The duration of hypotensive action of a single dose of guanfacine was 24–30 h allowing single daily dosing in several patients, while the duration of effect of azepexole was shorter (8 h). 4 After 8–10 weeks treatment with guanfacine was stopped. There was a gradual return of blood pressure to pre‐treatment levels over 4 days. 5 Both the sedative effect and the centrally mediated fall in blood pressure appear to result from activation of adrenoceptors of the α 2 subtype.