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Reversal of clonidine induced miosis by the alpha 2‐adrenoreceptor antagonist RX 781094.
Author(s) -
Clifford JM,
Day MD,
Orwin JM
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb04941.x
Subject(s) - miosis , clonidine , antagonist , placebo , anesthesia , pharmacology , alpha (finance) , medicine , surgery , receptor , construct validity , alternative medicine , pathology , patient satisfaction
Clonidine given i.v. at a dose of 0.1 mg and 0.2 mg was found to cause miosis in a placebo controlled double‐blind study in six healthy volunteers. In a further single‐blind placebo controlled study in three of these volunteers, the alpha 2‐adrenoreceptor antagonist RX 781094 at a dose of 0.1 mg/kg i.v. reversed the miosis induced by i.v. clonidine 0.2 mg. At a dose of 0.05 mg/kg the miosis was partially reversed.