Premium
Sustained haemodynamic and clinical effects of captopril in long‐term treatment of severe chronic congestive heart failure.
Author(s) -
Ricci S,
Zaniol P,
Teglio V,
Baraldi P,
Mattioli G
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb02079.x
Subject(s) - captopril , heart failure , medicine , cardiology , ejection fraction , hemodynamics , digitalis , diuretic , vascular resistance , digoxin , cardiac index , angiotensin converting enzyme , cardiac output , ace inhibitor , blood pressure
1 The angiotensin‐converting‐enzyme inhibitor captopril is known to produce beneficial haemodynamic effects in patients with chronic congestive heart failure. 2 Twelve patients with chronic congestive heart failure were conventionally treated with digitalis and diuretic therapy plus oral captopril (75‐150 mg/day), and 14 patients were used as a control group. 3 There was no improvement in functional and haemodynamic values in the controls, but the patients treated with captopril showed a significant functional improvement (increase of exercise time and improvement in New York Heart Association functional class), a definitive decrease in systemic vascular resistance (20%), and a significant increase in the cardiac index and ejection fraction (18% and 28% respectively).