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Long‐term experience of captopril in the treatment of primary (essential) hypertension.
Author(s) -
Karlberg BE,
Asplund J,
Wettre S,
Ohman KP,
Nilsson OR
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb02070.x
Subject(s) - hydrochlorothiazide , captopril , supine position , medicine , blood pressure , essential hypertension , thiazide , urology , plasma renin activity , renin–angiotensin system
1 Forty‐one patients with primary (essential) hypertension were treated with captopril alone or in combination with hydrochlorothiazide for 12‐ 36 months. 2 During an initial dose‐titration period mean blood pressure fell from 174/111 mm Hg to 134/88 mm Hg supine and from 170/116 mm Hg to 126/93 mm Hg standing after 3 months' treatment. 3 During long‐term treatment with unchanged or reduced doses of captopril or hydrochlorothiazide, or both, blood pressure remained substantially reduced. Mean supine blood pressure at 24 months was 136/90 mm Hg and at 36 months 138/90 mm Hg. 4 In 12 patients with clearly defined low renin (essential) hypertension initial blood pressure reduction was less than in patients with normal renin hypertension after 1 month's treatment (162/102 mm Hg v 143/92 mm Hg). After 24 months of treatment, however, the treatment results were similar in the two groups. 5 Except for one case of reversible proteinuria no serious side effects were seen during treatment periods of up to three years. 6 Captopril alone or in combination with hydrochlorothiazide seems to be an effective and safe drug in the long‐term treatment of primary hypertension.