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Long‐term captopril treatment in moderate to severe hypertension.
Author(s) -
Santucci A,
Aguglia F,
Mattia G,
Ficara C,
Balsano F
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb02061.x
Subject(s) - chlorthalidone , captopril , renovascular hypertension , medicine , diuretic , plasma renin activity , essential hypertension , blood pressure , endocrinology , renin–angiotensin system , potassium , sodium , basal (medicine) , angiotensin converting enzyme , urology , chemistry , diabetes mellitus , organic chemistry
1 The long‐term effects of the oral angiotensin‐converting enzyme inhibitor captopril with the addition of a diuretic (chlorthalidone) were examined in 16 patients with moderate or grave hypertension. Of these, 14 had essential hypertension and two renovascular hypertension. 2 Blood pressure fell sharply in all patients and this antihypertensive effect was maintained during 2, 4, 6, 12, and 24‐month follow‐up periods. The efficacy of treatment was not predicted by basal values of plasma renin activity. 3 Urinary excretion of sodium and potassium increased, but the increases were never such as to modify significantly sodium and potassium serum concentration. 4 The long‐term treatment was generally well tolerated.