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Effects of cold exposure on blood pressure, heart rate and forearm blood flow in normotensives during selective and non‐selective beta‐ adrenoceptor blockade.
Author(s) -
Houben H,
Thien T,
Wijnands G,
Van't Laar A
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb02051.x
Subject(s) - propranolol , metoprolol , blockade , heart rate , blood pressure , cold pressor test , hemodynamics , beta (programming language) , medicine , blood flow , forearm , endocrinology , beta blocker , chemistry , heart failure , receptor , surgery , computer science , programming language
Haemodynamic effects of a cold pressor test (foot immersion for 6 min in water at 5 degrees C) without medication and after the non‐selective beta‐adrenoceptor blocker propranolol and the selective beta‐ adrenoceptor blocker metoprolol were studied in 17 volunteers. In the control study as well as in the study with the beta‐adrenoceptor blockers cold exposure caused comparable changes, namely a blood pressure rise and a reduction of forearm blood flow. The increase in heart rate during cold exposure was clearly and equally reduced by both beta‐adrenoceptor blockers. Plasma noradrenaline rose significantly by 47%, plasma adrenaline did not change. It is concluded, that as to this kind of stress, beta 1‐selective‐adrenoceptor blockade confers no important advantage over non‐selective beta‐adrenoceptor blockade.