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The effect of once daily beta‐adrenoceptor blocker‐thiazide diuretic combination on the ambulatory blood pressure.
Author(s) -
Gould BA,
Hornung RS,
Kieso H,
Mann S,
Raftery EB
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb02044.x
Subject(s) - pindolol , blood pressure , medicine , diuretic , morning , thiazide , ambulatory blood pressure , ambulatory , heart rate , anesthesia , hydrochlorothiazide , propranolol
1 We have assessed the efficacy of Viskaldix, a combination of pindolol 10 mg and clopamide 5 mg using continuous intra‐arterial ambulatory blood pressure monitoring. 2 Fourteen of the sixteen patients entered were studied on no therapy and following a minimum of 6 weeks at a constant dosage of Viskaldix. 3 Viskaldix produced a marked and consistent reduction of the blood pressure over the 24 h. The diurnal variation in the heart rate was decreased. 4 The results were compared with those of a similar study with once‐daily pindolol where there was control during the day but not in the early morning when the blood pressures rose rapidly.