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A placebo controlled study of the cardiovascular effects of fluvoxamine and clovoxamine in human volunteers.
Author(s) -
Robinson JF,
Doogan DP
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb02040.x
Subject(s) - fluvoxamine , placebo , nausea , crossover study , blood pressure , medicine , anesthesia , pharmacology , serotonin , pathology , receptor , alternative medicine , fluoxetine
1 Fluvoxamine and clovoxamine, two new potential antidepressants were given to 27 healthy male volunteers in a double‐blind, placebo controlled, three‐way crossover study. 2 Neither compound affected the electrical intervals of 24 h ambulant electrocardiographic monitoring with the exception of a small increase in R‐R interval. 3 There were no changes in blood pressure measurements. 4 The only notable unwanted symptom was nausea for both fluvoxamine and clovoxamine.