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Urinary excretion of aspirin.
Author(s) -
Cham Elliot B,
Dykman JH,
Bochner F
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb02030.x
Subject(s) - urine , aspirin , urinary system , salicylic acid , chemistry , excretion , medicine , pharmacology , urine collection device , endocrinology , biochemistry
Six human volunteers were each given single oral doses of aspirin (ASA) ranging from 300‐1,500 mg. The unchanged ASA excreted in the urine was proportional to dose and urinary pH. The mean percent (+/‐ s.d.) of dose excreted was 1.9 +/‐ 0.67. The clearance for ASA was 1.42 +/‐ 0.28 1/h. The rate of in vitro hydrolysis of ASA to salicylic acid in urine at 37 degrees C was 4 micrograms/min for an initial ASA concentration of 7.5 mg in 100 ml human urine.