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Ventilatory and cardiovascular effects of BHT 933 in volunteers.
Author(s) -
Pleuvry BJ,
Redpath JB
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb02029.x
Subject(s) - blood pressure , sedation , medicine , pharmacology , anesthesia , ventilation (architecture) , mechanical engineering , engineering
In 12 healthy volunteers BHT 933 in doses of 5 and 10 mg had minimal effects on ventilation, a small fall in total volume occurred with the highest dose. BHT 933 (5 mg) reduced both systolic and diastolic blood pressure, but had little effect on autonomic reactivity tests, whereas the 10 mg dose reduced the response to these tests. Both doses of BHT 933 caused marked sedation. It is concluded that 5 mg BHT 933 orally presents the most suitable profile of activity for further studies into its usefulness as an anti‐tussive and antihypertensive.