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The acute effects of ethanol on acetanilide disposition in normal subjects, and in patients with liver disease.
Author(s) -
McKay J,
Rawlings MD,
Cobden I,
James OF
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb02019.x
Subject(s) - acetanilide , ethanol , liver disease , half life , oral administration , medicine , alcoholic liver disease , microsome , disposition , toxicokinetics , chemistry , endocrinology , pharmacokinetics , pharmacology , biochemistry , cirrhosis , enzyme , psychology , social psychology , organic chemistry
1 The effects of single doses (25 g and 50 g) oral ethanol on the disposition of acetanilide (50 mg/kg metabolic active mass) has been studied in normal subjects, and in patients with chronic non‐alcoholic liver disease. 2 In normal subjects, ethanol produced a dose‐dependent increase in acetanilide half‐life, and a decrease in acetenilide clearance. There was a significant correlation (rs = 0.71, P less than 0.01) between the 90 min blood ethanol concentration and the reduction in acetanilide clearance. 3 In patients with liver disease, ethanol produced a similar proportional change in acetanilide half‐life and clearance, but these were less consistent. Moreover, liver disease itself was associated with an increase in acetenilide half‐life, and a reduction in clearance. 4 It is concluded that single oral doses of ethanol, comparable to those consumed during social drinking, may inhibit some forms of microsomal oxidation and thus have important clinical implications.