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The influence of the menstrual cycle on the metabolism and clearance of methaqualone.
Author(s) -
Wilson K,
Oram M,
Horth CE,
Burnett D
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01988.x
Subject(s) - methaqualone , menstrual cycle , chemistry , endocrinology , medicine , metabolism , ovulation , excretion , chromatography , hormone
1 The rate of methaqualone metabolism in women was shown to be significantly increased at the time of ovulation. 2 The apparent first order rate constants for the formation of five C‐monohydroxy metabolites of methaqualone on day 15 of the menstrual cycle were approximately double that on day 1. 3 The N‐oxidation of methaqualone showed considerable inter‐individual variation in its sensitivity to the menstrual cycle, and in a group of ten women the difference in N‐ oxide excretion between days 1 and 15 was not statistically significant. 4 The serum clearance of methaqualone on day 15 was higher (mean value 94.6 ml min‐1 on day 1, 176.0 ml min‐1 on day 15), serum half‐life shorter (mean t1/2 beta 16.3 h on day 1, 11.6 h on day 15) and the AUC alpha smaller (mean value 44.0 micrograms ml‐1 h on day 1, 24.4 micrograms ml‐1 h on day 15) than on day 1. 5 The relative importance of the five hydroxy metabolites was unchanged during the menstrual cycle but the C/N oxidation ratio was greater on day 15 than on day 1. 6 The data for methaqualone metabolism in a control group of men was similar to than in women on day 1 of a menstrual cycle.