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Cimetidine does not increase the anticoagulant effect of phenprocoumon.
Author(s) -
Harenberg J,
Staiger C,
Vries JX,
Walter E,
Weber E,
Zimmermann R
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01979.x
Subject(s) - phenprocoumon , cimetidine , anticoagulant , warfarin , concomitant , drug interaction , medicine , pharmacology , drug , atrial fibrillation
In patients on oral warfarin, nicoumalone and phenindione an increase of the anticoagulant effect has been described during concomitant treatment with cimetidine. Therefore we have investigated the effect of cimetidine on the steady state dynamics of phenprocoumon in ten outpatients. No changes in the anticoagulant effect and the plasma phenprocoumon levels were observed during and after 2 weeks application of cimetidine. The data show that cimetidine does not interact with the metabolism of phenprocoumon in contrast to warfarin.