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Metabolism of digoxin and absorption site.
Author(s) -
Magnusson JO,
Bergdahl B,
Bogentoft C,
Jonsson UE
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01976.x
Subject(s) - digoxin , metabolism , absorption (acoustics) , excretion , chemistry , pharmacokinetics , pharmacology , urine , chromatography , medicine , endocrinology , biochemistry , materials science , heart failure , composite material
After oral intake of enteric‐coated granules containing [3H]‐digoxin extensive metabolism was observed. Maximum 66% of the 24 h urinary excretion was identified as [3H]‐dihydrodigoxin, using high performance liquid chromatography for the analysis. It is suggested that metabolism of digoxin may depend on the absorption site.