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Predictive indices for chlorpromazine therapy in schizophrenics.
Author(s) -
Dixon PA,
Oforah E,
Makanjuola R
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01973.x
Subject(s) - chlorpromazine , medicine , pharmacotherapy , pharmacology
1 Response to chlorpromazine therapy was studied in 24 schizophrenics and 75% reduction in Brief Psychiatric Rating scale (BPRS) within 4 weeks of treatment was taken to indicate good response. 2 Test oral dose of CPZ (200 mg) was administered and serial blood samples and total urine excreted in 6 h were taken for analyses of CPZ and its metabolites. 3 Area under the plasma time curve (AUC) showed an inverted U‐shaped relationship with % reduction in BPRS. 4 Three groups of patients were identified, responders, l‐ and h‐group non‐responders. 5 l‐ and h‐groups respond on further treatment with haloperidol (30 mg daily) and ECT respectively. 6 Responders showed threshold metabolic molar fraction MMFHO‐CPZ greater than or equal to 3.0 x 10(‐5) and MMFHO‐CPZ/MMFCPZ‐SO greater than 1.