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The effect of intravenous cimetidine on the absorption of orally administered diazepam and lorazepam.
Author(s) -
McGowan WA,
Dundee JW
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01963.x
Subject(s) - diazepam , cimetidine , lorazepam , absorption (acoustics) , pharmacology , capsule , pharmacokinetics , drug interaction , drug , medicine , chemistry , anesthesia , materials science , botany , composite material , biology
1 The effect of intravenous cimetidine 200 mg or 400 mg on the absorption of lorazepam 2.5 mg tablet and diazepam 10 mg tablet and capsule was studied. 2 Considerable individual variation in plasma concentrations was found with all preparations. 3 Cimetidine increased the absorption of diazepam and lorazepam. 4 Capsule preparations of diazepam generally produced higher drug plasma concentrations than the tablets.