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Beta‐adrenoceptor blockade in stress due to oral surgery.
Author(s) -
Brisse B,
Tetsch P,
Jacobs W,
Bender F
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01950.x
Subject(s) - metoprolol , medicine , pindolol , blockade , heart rate , anesthesia , oral administration , antagonist , endocrinology , blood pressure , propranolol , receptor
1 The effects of a single oral dose of 5 mg pindolol (P) and 100 mg metoprolol (M) were assessed in a double‐blind study in 30 patients undergoing oral surgery. 2 Systolic and diastolic blood pressures and heart rate were reduced 90 min after oral medication and did not exceed initial values at rest during the procedure. 3 Noradrenaline, adrenaline and c‐AMP concentrations did not differ at any time from the control values at rest after P, but were increased after local anaesthesia and during oral surgery after M as were the metabolic responses reflected by plasma concentrations of glucose and free‐fatty acids. 4 Plasma levels of ACTH and cortisol showed the typical increase during the procedure, being independent of beta‐adrenoceptor blockade. In contrast to the cardioselective antagonist M, prophylactic administration of the non‐selective drug P prevented the sympathetic and metabolic responses to the stress of oral surgery. 5 Hypothalamic and adrenal stimulation were not reduced by either selective or non‐ selective beta‐adrenoceptor blockade.