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The effect of pindolol on myocardial blood flow, metabolism and function during rest and pacing in patients with coronary heart disease.
Author(s) -
Kupper W,
Hamm CW,
Bleifeld W
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01932.x
Subject(s) - pindolol , angina , medicine , cardiology , blood flow , hemodynamics , coronary circulation , propranolol , myocardial infarction
1 The study was designed to elucidate further the mechanism by which beta‐adrenoceptor antagonism with pindolol relieves the symptoms of angina pectoris in patients with coronary heart disease. 2 Pindolol administration was associated with an elevated threshold for angina pectoris and improved myocardial lactate metabolism during supraventricular pacing. 3 This beneficial effect of pindolol was independent of changes in myocardial blood flow and was not mediated by haemodynamic effects. 4 The results suggest that in angina pectoris, in addition to the recognized beneficial effects of beta‐adrenoceptor blockade, the actions of pindolol also result from, as yet, poorly described phenomena such as redistribution of myocardial blood flow or metabolic effects.