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The influence of beta‐adrenoceptor blockade on left ventricular function.
Author(s) -
Hahn B,
Strauer BE
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01931.x
Subject(s) - pindolol , metoprolol , cardiology , medicine , heart rate , blood pressure , beta (programming language) , blockade , cardiac function curve , heart failure , anesthesia , propranolol , receptor , computer science , programming language
1 This study was designed to compare in a randomized cross‐over trial pindolol, a beta‐adrenoceptor blocking agent with intrinsic sympathomimetic activity and metoprolol, a cardioselective beta‐ adrenoceptor blocker lacking sympathomimetic activity in hypertensives with incipient heart failure. Cardiac function was investigated by M‐ Mode and 2D‐echo‐cardiography. 2 Both pindolol and metoprolol in equipotent doses lowered blood pressure to the same extent. 3 There was no difference in overall left ventricular function in ventricular geometry or in wall dynamics after either drug. 4 In comparison to metoprolol, pindolol produced less reduction in resting heart rate, cardiac index and ejection velocity reflecting the intrinsic sympathomimetic activity of the drug.