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Renal haemodynamics after chronic treatment with labetalol and propranolol.
Author(s) -
Malini PL,
Strocchi E,
Negroni S,
Ambrosioni E,
Magnani B
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01900.x
Subject(s) - labetalol , propranolol , effective renal plasma flow , placebo , medicine , renal blood flow , blood pressure , hemodynamics , vascular resistance , renal function , anesthesia , urology , alternative medicine , pathology
1 Effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) were measured in two groups of 12 patients both at rest and during sub‐maximal cycloergometer exercise while on placebo and after 3 months of treatment with either labetalol or propranolol. 2 ERPF increased and renal vascular resistance decreased both at rest and during exercise after labetalol treatment, compared with placebo; the opposite was observed after propranolol treatment. 3 GFR increased after labetalol and decreased after propranolol both at rest and during exercise, compared with placebo, but these changes were not statistically significant. 4 Labetalol and propranolol resulted in the same decrease in blood pressure and a comparable incidence of side effects.