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Labetalol in general practice: a review.
Author(s) -
Kane JA
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01890.x
Subject(s) - labetalol , medicine , blood pressure , anesthesia , adverse effect , antihypertensive drug , clinical practice , diastole , general practice , physical therapy , family medicine
1 The results of the treatment of 8573 hypertensive patients with labetalol in general practice, for periods between 1 month and 5 yr, are reviewed. 2 The data reviewed were obtained from the published literature together with our own published (Kane et al., 1976; Kane et al., 1979) and more recent (unpublished) work. 3 Between 60% and 80% of severe (diastolic blood pressure greater than 120 mmHg) and previously uncontrolled hypertensives responded satisfactorily to the drug, as did up to 88% of mild to moderate hypertensives. 4 The anti‐hypertensive effect of labetalol was not dependent on the frequency of administration, twice and three times daily treatment regimes being equally effective. 5 The withdrawal rate attributable to side‐effects was between 6% and 13%. Tiredness, dizziness, headache and upper gastro‐ intestinal symptoms were the four principal side‐effects, but they were usually transient when labetalol treatment was continued. 6 No drug interactions or adverse haematological or biochemical changes were seen.