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A review of the haemodynamic effects of labetalol in man.
Author(s) -
Cohn JN,
Mehta J,
Francis GS
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01885.x
Subject(s) - labetalol , isoprenaline , medicine , blood pressure , heart rate , hemodynamics , supine position , tachycardia , phenylephrine , anesthesia , cardiac output , cardiology , stimulation
1 Labetalol at a dose of 800 to 1600 mg daily inhibited isoprenaline‐ induced tachycardia and phenylephrine‐induced elevation in arterial pressure in hypertensive subjects. The beta‐adrenoreceptor effect was four times more potent than the alpha‐adrenoreceptor effect. 2 Isoprenaline‐induced tachycardia was more effectively blocked than isoprenaline‐induced inotropism, thereby raising the possibility of a subselective effect on cardiac beta‐adrenoceptors. 3 Labetalol reduced blood pressure in hypertensive subjects with no change in cardiac output in the supine or upright position and with marked inhibition of the heart rate and blood pressure response to treadmill exercise. 4 Labetalol administered in single doses to patients with stable, treated congestive heart failure impaired blood pressure support during exercise. 5 The unique adrenoceptor and haemodynamic effects of labetalol make it a potentially attractive drug for management of hypertension and other cardiovascular disorders.