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Response of the systemic pulmonary circulation to labetalol at rest and during exercise.
Author(s) -
Fagard R,
Lijnen P,
Amery A
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01884.x
Subject(s) - labetalol , medicine , vascular resistance , pulmonary wedge pressure , heart rate , sitting , cardiac output , blood pressure , phenylephrine , plasma renin activity , cardiology , hemodynamics , anesthesia , mean arterial pressure , renin–angiotensin system , pathology
1 Labetalol was administered to 18 hypertensive patients for an average duration of 2.44 weeks, with an average final daily dose of 1.65 g (principally to study its short‐term haemodynamic effects). 2 Labetalol decreased resting heart rate by 16% and maximal exercise heart rate by 21%; the phenylephrine‐induced increase in systolic brachial arterial pressure was reduced by 36%. 3 During labetalol treatment brachial arterial pressure was decreased by 29/15 mmHg in the recumbent position, by 41/23 mmHg at rest sitting and by 53/23 mmHg at maximal exercise; total peripheral resistance was not significantly affected at rest recumbent but was reduced at sitting and at exercise; cardiac output was decreased in all conditions. 4 Labetalol reduced mean pulmonary arterial and capillary wedge pressures only in the sitting position. Pulmonary vascular resistance remained unchanged. 5 The drug produced significant decreases in plasma renin activity and in plasma aldosterone concentration.