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An assessment of beta‐adrenoceptor blockade in man by prizidilol hydrochloride.
Author(s) -
Pitcher DW,
Curry PV,
Trounce JR
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01441.x
Subject(s) - hydrochloride , beta (programming language) , pharmacology , adrenergic receptor , blockade , medicine , adrenergic beta antagonists , chemistry , propranolol , receptor , computer science , biochemistry , programming language
1 Prizidilol hydrochloride (SK&F 92657) is a new compound which causes both arteriolar dilatation and beta‐adrenoceptor blockade. The effect of a single oral dose on the responses of heart rate and blood pressure to isoprenaline infusion has been studied in healthy volunteers. 2 Isoprenaline heart rate dose‐response curves showed parallel shifts to the right after oral prizidilol, indicating antagonism by this compound at beta‐adrenoceptors in the heart. 3 Isoprenaline dose‐response curves for decreases in diastolic blood pressure also showed shifts to the right after oral prizidilol, providing evidence of beta‐adrenoceptor antagonism by this drug in peripheral resistance vessels. 4 The peak effect of a 40 mg dose of propranolol was greater than that of a 200 mg dose of prizidilol but both drugs caused persistent beta‐adrenoceptor blockade for at least 7 h after ingestion.