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Effect of long‐term cimetidine treatment on left ventricular function in haemodialysis patients with active hyperparathyroidism.
Author(s) -
Lai KN,
Fassett RG,
Mathew TH
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01438.x
Subject(s) - medicine , hyperparathyroidism , cimetidine , ejection fraction , cardiology , radionuclide ventriculography , secondary hyperparathyroidism , parathyroid hormone , cardiac function curve , endocrinology , heart failure , calcium
1 The effect of long‐term oral cimetidine on left ventricular function was evaluated in chronic haemodialysis patients with active hyperparathyroidism. 2 Radionuclide ventriculography (seven patients) and echocardiography (five patients) revealed a significant increase in ejection fraction and mean velocity of circumferential fibre shortening six months after treatment. 3 The improved cardiac performance was associated with improvement of bone histology. C‐terminal parathyroid hormone, serum calcium, and mean arterial pressure changed little after treatment. 4 The improved cardiac performance is thought to be related to the suppression of uraemic hyperparathyroidism by cimetidine. 5 The present study suggests that uraemic hyperparathyroidism may play an important role in “uraemic cardiomyopathy”.