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The effects of domperidone on gastric emptying of liquid in man.
Author(s) -
Bateman DN,
Gooptu D,
Whittingham TA
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01435.x
Subject(s) - domperidone , gastric emptying , saline , stomach , medicine , prokinetic agent , anesthesia , gastroenterology , dopamine
1 The effects of domperidone (20 mg) i.v. and saline i.v. on gastric emptying of 500 ml of fluid have been compared in a blind study in six normal male volunteers. 2 Gastric emptying was measured by real‐time ultrasound. 3 Domperidone significantly reduced the volume in the stomach 5 min after the drink (domperidone 306 +/‐ 17 ml, saline 404 +/‐ 31 ml, P less than 0.02). 4 Domperidone had no significant effect on the half‐life of gastric emptying measured between 5 and 60 min (T1/2 domperidone 21.2 +/‐ 1.17 min, T1/2 saline 21.3 +/‐ 1.58 min). 5 A similar pattern of gastric emptying to that produced by domperidone could be produced by giving a drink of a smaller volume.