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Serum protein binding and free concentration of phenytoin and phenobarbitone in pregnancy.
Author(s) -
Chen SS,
Perucca E,
Lee JN,
Richens A
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01420.x
Subject(s) - phenytoin , free fraction , pregnancy , albumin , endocrinology , gestation , medicine , plasma protein binding , anticonvulsant , serum albumin , serum concentration , drug , phenobarbital , gestational age , chemistry , pharmacology , epilepsy , biology , psychiatry , genetics
1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women. 2 The binding of both drugs was reduced during pregnancy. The reduction correlated positively with the gestational age and negatively with the serum albumin concentration. 3 In spite of the increase in unbound fraction, both the total and free serum concentrations of phenytoin were decreased in late pregnancy.